TECHICAL Series MATHEMATICS • INFORMATICS • PHYSICS Series PHILOLOGY Series ECONOMIC SCIENCES Sereies EDUCATIONAL SCIENCES Series LAW AND SOCIAL SCIENCES Series
Biocomposites based on Polyurethane for Bone Tissue Engineering Applications
(Biocompozite pe bază de poliuretan cu aplicaţii în ingineria tisulară osoasă)
Vol LXII • No. 3A/2010
Gabriela Ciobanu, Dorina Ignat, Constantin Luca, Gabriela Carja
"Gheorghe Asachi" Technical University of Iasi, Faculty of Chemical Engineering and Environmental Protection, Str. Prof. dr. doc. Dimitrie Mangeron, no. 73, Iasi, Romania
e-mail: gciobanu03@yahoo.co.uk

 Keywords   polyurethane, hydroxyapatite, biocomposites.

 Abstract
The main aim of this work is to develop and characterise biocomposites for tissue engineering applications. The biocomposites are made of a polyurethane polymer and a hydroxyapatite. By combining a polymer and a ceramic material can be formed biocomposites for bone tissue engineering applications, since the structure of bone can be grossly described as a collagen-hydroxyapatite composite. Structural properties and degradation rates in vitro of the composites were determined. The in vitro biodegradation of the composite in the phosphate buffered saline solution increased with incubation time and the rate differed with the coating concentration. The results demonstrate that the scaffold with low hydroxyapatite content will have higher degradation rate than that with high hydroxyapatite content.

 Rezumat
În lucrarea de faţă se prezintă un studiu privind caracterizarea unor biocompozite din poliuretan şi hidroxiapatită cu aplicaţii în ingineria tisulară. Au fost determinate proprietăţile structurale şi comportarea la degradare in vitro. Biodegradarea compozitelor în soluţie salină tamponată cu fosfat creşte cu timpul de incubare, depinzând de cantitatea de hidroxiapatită de pe suportul polimeric. Rezultatele demonstrează că materialele compozite cu conţinut scăzut în hidroxiapatită au o rată de degradare mai mare decât cele cu conţinut ridicat în hidroxiapatită.



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